AustralieFrV1, Main, Exploration, bibRecord, 002462

A meta-analysis of individual participant data reveals an association between circulating levels of IGF-I and prostate cancer risk

Identifieur interne : 002462 ( Main/Exploration ); précédent : 002461; suivant : 002463

A meta-analysis of individual participant data reveals an association between circulating levels of IGF-I and prostate cancer risk

Auteurs : Ruth C. Travis [Royaume-Uni] ; Paul N. Appleby [Royaume-Uni] ; Richard M. Martin [Royaume-Uni] ; Jeff M. P. Holly [Royaume-Uni] ; Demetrius Albanes [États-Unis] ; Amanda Black [États-Unis] ; H. B As Bueno-De-Mesquita [Malaisie, Royaume-Uni] ; June M. Chan [États-Unis] ; Chu Chen [États-Unis] ; Maria-Dolores Chirlaque [Espagne] ; Michael B. Cook [États-Unis] ; Mélanie Deschasaux [France] ; Jenny L. Donovan [Royaume-Uni] ; Luigi Ferrucci [États-Unis] ; Pilar Galan [France] ; Graham G. Giles [Australie] ; Edward L. Giovannucci [États-Unis] ; Marc J. Gunter [Royaume-Uni] ; Laurel A. Habel [États-Unis] ; Freddie C. Hamdy [Royaume-Uni] ; Kathy J. Helzlsouer [États-Unis] ; Serge Hercberg [France] ; Robert N. Hoover [États-Unis] ; Joseph A. M. J. L. Janssen [Pays-Bas] ; Rudolf Kaaks [Allemagne] ; Tatsuhiko Kubo [Japon] ; Loic Le Marchand [États-Unis] ; E. Jeffrey Metter [États-Unis] ; Kazuya Mikami [Japon] ; Joan K. Morris [Royaume-Uni] ; David E. Neal [Royaume-Uni] ; Marian L. Neuhouser [États-Unis] ; Kotaro Ozasa [Japon] ; Domenico Palli [Italie] ; Elizabeth A. Platz [États-Unis] ; Michael Pollak [Canada] ; Alison J. Price [Royaume-Uni] ; Monique J. Roobol [Pays-Bas] ; Catherine Schaefer [États-Unis] ; Jeannette M. Schenk [États-Unis] ; Gianluca Severi [Australie, Italie] ; Meir J. Stampfer [États-Unis] ; P R Stattin [Suède] ; Akiko Tamakoshi [Japon] ; Catherine M. Tangen [États-Unis] ; Mathilde Touvier [France] ; Nicholas J. Wald [Royaume-Uni] ; Noel S. Weiss [Italie] ; Regina G. Ziegler [États-Unis] ; Timothy J. Key [Royaume-Uni] ; Naomi E. Allen [Royaume-Uni]

Source :

Cancer research [ 0008-5472 ] ; 2016.

RBID : PMC:4873385

Descripteurs français

KwdFr :
- Adulte d'âge moyen, Facteur de croissance IGF-I (métabolisme), Facteurs de risque, Humains, Mâle, Sujet âgé, Tumeurs de la prostate (sang), Tumeurs de la prostate (épidémiologie).
MESH :
- métabolisme : Facteur de croissance IGF-I.
- sang : Tumeurs de la prostate.
- épidémiologie : Tumeurs de la prostate.
- Adulte d'âge moyen, Facteurs de risque, Humains, Mâle, Sujet âgé.

English descriptors

KwdEn :
- Aged, Humans, Insulin-Like Growth Factor I (metabolism), Male, Middle Aged, Prostatic Neoplasms (blood), Prostatic Neoplasms (epidemiology), Risk Factors.
MESH :
- chemical , metabolism : Insulin-Like Growth Factor I.
- blood : Prostatic Neoplasms.
- epidemiology : Prostatic Neoplasms.
- Aged, Humans, Male, Middle Aged, Risk Factors.

Abstract

The role of insulin-like growth factors (IGFs) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, IGFBP-3) and prostate cancer risk, we pooled individual participant data from 17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 control participants. Conditional logistic regression was used to estimate the odds ratios (ORs) for prostate cancer based on the study-specific fifth of each analyte. Overall, IGF-I, IGF-II, IGFBP-2, and IGFBP-3 concentrations were positively associated with prostate cancer risk (Ptrend all ≤ 0.005), and IGFBP-1 was weakly inversely associated with risk (Ptrend = 0.05). However, heterogeneity between the prospective and cross-sectional studies was evident (Pheterogeneity = 0.03), unless the analyses were restricted to prospective studies (with the exception of IGF-II, Pheterogeneity = 0.02). For prospective studies, the OR for men in the highest versus the lowest fifth of each analyte was 1.29 (95% confidence interval=1.16-1.43) for IGF-I, 0.81 (0.68-0.96) for IGFBP-1, and 1.25 (1.12-1.40) for IGFBP-3. These associations did not differ significantly by time-to-diagnosis or tumor stage or grade. After mutual adjustment for each of the other analytes, only IGF-I remained associated with risk. Our collaborative study represents the largest pooled analysis of the relationship between prostate cancer risk and circulating concentrations of IGF-I, providing strong evidence that IGF-I is highly likely to be involved in prostate cancer development.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873385

DOI: 10.1158/0008-5472.CAN-15-1551
PubMed: 26921328
PubMed Central: 4873385

Affiliations:

Le document en format XML

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<author><name sortKey="Chen, Chu" sort="Chen, Chu" uniqKey="Chen C" first="Chu" last="Chen">Chu Chen</name>
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<author><name sortKey="Cook, Michael B" sort="Cook, Michael B" uniqKey="Cook M" first="Michael B." last="Cook">Michael B. Cook</name>
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<author><name sortKey="Deschasaux, Melanie" sort="Deschasaux, Melanie" uniqKey="Deschasaux M" first="Mélanie" last="Deschasaux">Mélanie Deschasaux</name>
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<author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L." last="Giovannucci">Edward L. Giovannucci</name>
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<wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea>
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<affiliation wicri:level="2"><nlm:aff id="A15">Department of Nutrition and Department of Medicine, Harvard School of Public Health, Boston, MA, USA</nlm:aff>
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<wicri:regionArea>Department of Nutrition and Department of Medicine, Harvard School of Public Health, Boston, MA</wicri:regionArea>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J." last="Gunter">Marc J. Gunter</name>
<affiliation wicri:level="3"><nlm:aff id="A7">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
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<author><name sortKey="Habel, Laurel A" sort="Habel, Laurel A" uniqKey="Habel L" first="Laurel A." last="Habel">Laurel A. Habel</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Research, Kaiser Permanente, Northern California, Oakland, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
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<author><name sortKey="Hamdy, Freddie C" sort="Hamdy, Freddie C" uniqKey="Hamdy F" first="Freddie C." last="Hamdy">Freddie C. Hamdy</name>
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<placeName><settlement type="city">Oxford</settlement>
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<author><name sortKey="Helzlsouer, Kathy J" sort="Helzlsouer, Kathy J" uniqKey="Helzlsouer K" first="Kathy J." last="Helzlsouer">Kathy J. Helzlsouer</name>
<affiliation wicri:level="2"><nlm:aff id="A18">The Prevention and Research Center, Mercy Medical Center, Baltimore, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Prevention and Research Center, Mercy Medical Center, Baltimore, MD</wicri:regionArea>
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<author><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name>
<affiliation wicri:level="3"><nlm:aff id="A11">Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny</wicri:regionArea>
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<author><name sortKey="Hoover, Robert N" sort="Hoover, Robert N" uniqKey="Hoover R" first="Robert N." last="Hoover">Robert N. Hoover</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Janssen, Joseph A M J L" sort="Janssen, Joseph A M J L" uniqKey="Janssen J" first="Joseph A. M. J. L." last="Janssen">Joseph A. M. J. L. Janssen</name>
<affiliation wicri:level="3"><nlm:aff id="A19">Erasmus MC, Dept Internal Medicine, Rotterdam, the Netherlands</nlm:aff>
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<wicri:regionArea>Erasmus MC, Dept Internal Medicine, Rotterdam</wicri:regionArea>
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<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
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<author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg</wicri:regionArea>
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<author><name sortKey="Kubo, Tatsuhiko" sort="Kubo, Tatsuhiko" uniqKey="Kubo T" first="Tatsuhiko" last="Kubo">Tatsuhiko Kubo</name>
<affiliation wicri:level="1"><nlm:aff id="A21">University of Occupational and Environmental Health, Kitakyushu, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>University of Occupational and Environmental Health, Kitakyushu</wicri:regionArea>
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<author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name>
<affiliation wicri:level="2"><nlm:aff id="A22">University of Hawaii Cancer Center, Honolulu, HI, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Hawaii Cancer Center, Honolulu, HI</wicri:regionArea>
<placeName><region type="state">Hawaï</region>
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</affiliation>
</author>
<author><name sortKey="Metter, E Jeffrey" sort="Metter, E Jeffrey" uniqKey="Metter E" first="E. Jeffrey" last="Metter">E. Jeffrey Metter</name>
<affiliation wicri:level="2"><nlm:aff id="A12">Intramural Research Program, National Institute on Aging, Baltimore, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Intramural Research Program, National Institute on Aging, Baltimore, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A23">Department of Neurology, University of Tennessee Health Science Center, Memphis, TN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Tennessee Health Science Center, Memphis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mikami, Kazuya" sort="Mikami, Kazuya" uniqKey="Mikami K" first="Kazuya" last="Mikami">Kazuya Mikami</name>
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<author><name sortKey="Morris, Joan K" sort="Morris, Joan K" uniqKey="Morris J" first="Joan K." last="Morris">Joan K. Morris</name>
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<author><name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E." last="Neal">David E. Neal</name>
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<author><name sortKey="Neuhouser, Marian L" sort="Neuhouser, Marian L" uniqKey="Neuhouser M" first="Marian L." last="Neuhouser">Marian L. Neuhouser</name>
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<author><name sortKey="Ozasa, Kotaro" sort="Ozasa, Kotaro" uniqKey="Ozasa K" first="Kotaro" last="Ozasa">Kotaro Ozasa</name>
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<author><name sortKey="Platz, Elizabeth A" sort="Platz, Elizabeth A" uniqKey="Platz E" first="Elizabeth A." last="Platz">Elizabeth A. Platz</name>
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<author><name sortKey="Pollak, Michael" sort="Pollak, Michael" uniqKey="Pollak M" first="Michael" last="Pollak">Michael Pollak</name>
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<author><name sortKey="Price, Alison J" sort="Price, Alison J" uniqKey="Price A" first="Alison J." last="Price">Alison J. Price</name>
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<author><name sortKey="Roobol, Monique J" sort="Roobol, Monique J" uniqKey="Roobol M" first="Monique J." last="Roobol">Monique J. Roobol</name>
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<author><name sortKey="Schaefer, Catherine" sort="Schaefer, Catherine" uniqKey="Schaefer C" first="Catherine" last="Schaefer">Catherine Schaefer</name>
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<author><name sortKey="Schenk, Jeannette M" sort="Schenk, Jeannette M" uniqKey="Schenk J" first="Jeannette M." last="Schenk">Jeannette M. Schenk</name>
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<author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
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<author><name sortKey="Stampfer, Meir J" sort="Stampfer, Meir J" uniqKey="Stampfer M" first="Meir J." last="Stampfer">Meir J. Stampfer</name>
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<author><name sortKey="Stattin, P R" sort="Stattin, P R" uniqKey="Stattin P" first="P R" last="Stattin">P R Stattin</name>
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<country xml:lang="fr">Suède</country>
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<author><name sortKey="Tamakoshi, Akiko" sort="Tamakoshi, Akiko" uniqKey="Tamakoshi A" first="Akiko" last="Tamakoshi">Akiko Tamakoshi</name>
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<author><name sortKey="Tangen, Catherine M" sort="Tangen, Catherine M" uniqKey="Tangen C" first="Catherine M." last="Tangen">Catherine M. Tangen</name>
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<author><name sortKey="Wald, Nicholas J" sort="Wald, Nicholas J" uniqKey="Wald N" first="Nicholas J." last="Wald">Nicholas J. Wald</name>
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<author><name sortKey="Weiss, Noel S" sort="Weiss, Noel S" uniqKey="Weiss N" first="Noel S." last="Weiss">Noel S. Weiss</name>
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<author><name sortKey="Ziegler, Regina G" sort="Ziegler, Regina G" uniqKey="Ziegler R" first="Regina G." last="Ziegler">Regina G. Ziegler</name>
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<author><name sortKey="Key, Timothy J" sort="Key, Timothy J" uniqKey="Key T" first="Timothy J." last="Key">Timothy J. Key</name>
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<settlement type="city">Oxford</settlement>
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<author><name sortKey="Allen, Naomi E" sort="Allen, Naomi E" uniqKey="Allen N" first="Naomi E." last="Allen">Naomi E. Allen</name>
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<settlement type="city">Oxford</settlement>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A meta-analysis of individual participant data reveals an association between circulating levels of IGF-I and prostate cancer risk</title>
<author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford</wicri:regionArea>
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<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Appleby, Paul N" sort="Appleby, Paul N" uniqKey="Appleby P" first="Paul N." last="Appleby">Paul N. Appleby</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
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<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
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</author>
<author><name sortKey="Martin, Richard M" sort="Martin, Richard M" uniqKey="Martin R" first="Richard M." last="Martin">Richard M. Martin</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
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</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A3">Medical Research Council/University of Bristol Integrative Epidemiology Unit, University of Bristol, and National Institute for Health Research, Bristol Biomedical Research Unit in Nutrition, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Medical Research Council/University of Bristol Integrative Epidemiology Unit, University of Bristol, and National Institute for Health Research, Bristol Biomedical Research Unit in Nutrition, Bristol</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Holly, Jeff M P" sort="Holly, Jeff M P" uniqKey="Holly J" first="Jeff M. P." last="Holly">Jeff M. P. Holly</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Clinical Science, Faculty of Medicine, University of Bristol, Bristol</wicri:regionArea>
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</author>
<author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Black, Amanda" sort="Black, Amanda" uniqKey="Black A" first="Amanda" last="Black">Amanda Black</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bueno De Mesquita, H B As" sort="Bueno De Mesquita, H B As" uniqKey="Bueno De Mesquita H" first="H. B As" last="Bueno-De-Mesquita">H. B As Bueno-De-Mesquita</name>
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<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Dt. for Determinants of Chronic Diseases, National Institute for Public Health and the Environment (RIVM), Bilthoven, and Dt. of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands, and Dt. of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur</wicri:regionArea>
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<affiliation wicri:level="3"><nlm:aff id="A7">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
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<author><name sortKey="Chan, June M" sort="Chan, June M" uniqKey="Chan J" first="June M." last="Chan">June M. Chan</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Epidemiology & Biostatistics and Urology, University of California San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chen, Chu" sort="Chen, Chu" uniqKey="Chen C" first="Chu" last="Chen">Chu Chen</name>
<affiliation wicri:level="2"><nlm:aff id="A9">Division of Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chirlaque, Maria Dolores" sort="Chirlaque, Maria Dolores" uniqKey="Chirlaque M" first="Maria-Dolores" last="Chirlaque">Maria-Dolores Chirlaque</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, and CIBER Epidemiología y Salud Pública, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, and CIBER Epidemiología y Salud Pública</wicri:regionArea>
<wicri:noRegion>and CIBER Epidemiología y Salud Pública</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cook, Michael B" sort="Cook, Michael B" uniqKey="Cook M" first="Michael B." last="Cook">Michael B. Cook</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Deschasaux, Melanie" sort="Deschasaux, Melanie" uniqKey="Deschasaux M" first="Mélanie" last="Deschasaux">Mélanie Deschasaux</name>
<affiliation wicri:level="3"><nlm:aff id="A11">Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Bobigny</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Donovan, Jenny L" sort="Donovan, Jenny L" uniqKey="Donovan J" first="Jenny L." last="Donovan">Jenny L. Donovan</name>
<affiliation wicri:level="1"><nlm:aff id="A2">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name>
<affiliation wicri:level="2"><nlm:aff id="A12">Intramural Research Program, National Institute on Aging, Baltimore, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Intramural Research Program, National Institute on Aging, Baltimore, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Galan, Pilar" sort="Galan, Pilar" uniqKey="Galan P" first="Pilar" last="Galan">Pilar Galan</name>
<affiliation wicri:level="3"><nlm:aff id="A11">Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Bobigny</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
<affiliation wicri:level="4"><nlm:aff id="A13">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, and Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, and Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L." last="Giovannucci">Edward L. Giovannucci</name>
<affiliation wicri:level="2"><nlm:aff id="A14">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A15">Department of Nutrition and Department of Medicine, Harvard School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Nutrition and Department of Medicine, Harvard School of Public Health, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J." last="Gunter">Marc J. Gunter</name>
<affiliation wicri:level="3"><nlm:aff id="A7">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Habel, Laurel A" sort="Habel, Laurel A" uniqKey="Habel L" first="Laurel A." last="Habel">Laurel A. Habel</name>
<affiliation wicri:level="2"><nlm:aff id="A16">Division of Research, Kaiser Permanente, Northern California, Oakland, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Research, Kaiser Permanente, Northern California, Oakland, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hamdy, Freddie C" sort="Hamdy, Freddie C" uniqKey="Hamdy F" first="Freddie C." last="Hamdy">Freddie C. Hamdy</name>
<affiliation wicri:level="4"><nlm:aff id="A17">Nuffield Department of Surgery, University of Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Nuffield Department of Surgery, University of Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Helzlsouer, Kathy J" sort="Helzlsouer, Kathy J" uniqKey="Helzlsouer K" first="Kathy J." last="Helzlsouer">Kathy J. Helzlsouer</name>
<affiliation wicri:level="2"><nlm:aff id="A18">The Prevention and Research Center, Mercy Medical Center, Baltimore, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Prevention and Research Center, Mercy Medical Center, Baltimore, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name>
<affiliation wicri:level="3"><nlm:aff id="A11">Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Bobigny</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hoover, Robert N" sort="Hoover, Robert N" uniqKey="Hoover R" first="Robert N." last="Hoover">Robert N. Hoover</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Janssen, Joseph A M J L" sort="Janssen, Joseph A M J L" uniqKey="Janssen J" first="Joseph A. M. J. L." last="Janssen">Joseph A. M. J. L. Janssen</name>
<affiliation wicri:level="3"><nlm:aff id="A19">Erasmus MC, Dept Internal Medicine, Rotterdam, the Netherlands</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Erasmus MC, Dept Internal Medicine, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name>
<affiliation wicri:level="3"><nlm:aff id="A20">Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kubo, Tatsuhiko" sort="Kubo, Tatsuhiko" uniqKey="Kubo T" first="Tatsuhiko" last="Kubo">Tatsuhiko Kubo</name>
<affiliation wicri:level="1"><nlm:aff id="A21">University of Occupational and Environmental Health, Kitakyushu, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>University of Occupational and Environmental Health, Kitakyushu</wicri:regionArea>
<wicri:noRegion>Kitakyushu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name>
<affiliation wicri:level="2"><nlm:aff id="A22">University of Hawaii Cancer Center, Honolulu, HI, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Hawaii Cancer Center, Honolulu, HI</wicri:regionArea>
<placeName><region type="state">Hawaï</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Metter, E Jeffrey" sort="Metter, E Jeffrey" uniqKey="Metter E" first="E. Jeffrey" last="Metter">E. Jeffrey Metter</name>
<affiliation wicri:level="2"><nlm:aff id="A12">Intramural Research Program, National Institute on Aging, Baltimore, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Intramural Research Program, National Institute on Aging, Baltimore, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A23">Department of Neurology, University of Tennessee Health Science Center, Memphis, TN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Tennessee Health Science Center, Memphis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mikami, Kazuya" sort="Mikami, Kazuya" uniqKey="Mikami K" first="Kazuya" last="Mikami">Kazuya Mikami</name>
<affiliation wicri:level="1"><nlm:aff id="A24">Kyoto Prefectural University of Medicine, Kyoto, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Kyoto Prefectural University of Medicine, Kyoto</wicri:regionArea>
<wicri:noRegion>Kyoto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Morris, Joan K" sort="Morris, Joan K" uniqKey="Morris J" first="Joan K." last="Morris">Joan K. Morris</name>
<affiliation wicri:level="4"><nlm:aff id="A25">Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">Université de Londres</orgName>
</affiliation>
</author>
<author><name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E." last="Neal">David E. Neal</name>
<affiliation wicri:level="4"><nlm:aff id="A26">Department of Oncology, University of Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Oncology, University of Cambridge</wicri:regionArea>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
<orgName type="university">Université de Cambridge</orgName>
</affiliation>
</author>
<author><name sortKey="Neuhouser, Marian L" sort="Neuhouser, Marian L" uniqKey="Neuhouser M" first="Marian L." last="Neuhouser">Marian L. Neuhouser</name>
<affiliation wicri:level="2"><nlm:aff id="A9">Division of Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ozasa, Kotaro" sort="Ozasa, Kotaro" uniqKey="Ozasa K" first="Kotaro" last="Ozasa">Kotaro Ozasa</name>
<affiliation wicri:level="1"><nlm:aff id="A27">Radiation Effects Research Foundation, Hiroshima, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Radiation Effects Research Foundation, Hiroshima</wicri:regionArea>
<wicri:noRegion>Hiroshima</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Palli, Domenico" sort="Palli, Domenico" uniqKey="Palli D" first="Domenico" last="Palli">Domenico Palli</name>
<affiliation wicri:level="1"><nlm:aff id="A28">Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence</wicri:regionArea>
<wicri:noRegion>Florence</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Platz, Elizabeth A" sort="Platz, Elizabeth A" uniqKey="Platz E" first="Elizabeth A." last="Platz">Elizabeth A. Platz</name>
<affiliation wicri:level="2"><nlm:aff id="A29">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pollak, Michael" sort="Pollak, Michael" uniqKey="Pollak M" first="Michael" last="Pollak">Michael Pollak</name>
<affiliation wicri:level="4"><nlm:aff id="A30">Departments of Medicine and Oncology, McGill University, Montreal, QC, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Departments of Medicine and Oncology, McGill University, Montreal, QC</wicri:regionArea>
<orgName type="university">Université McGill</orgName>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Price, Alison J" sort="Price, Alison J" uniqKey="Price A" first="Alison J." last="Price">Alison J. Price</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Roobol, Monique J" sort="Roobol, Monique J" uniqKey="Roobol M" first="Monique J." last="Roobol">Monique J. Roobol</name>
<affiliation wicri:level="1"><nlm:aff id="A31">Erasmus MC, Dept of Urology Rotterdam, the Netherlands</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Erasmus MC, Dept of Urology Rotterdam</wicri:regionArea>
<wicri:noRegion>Dept of Urology Rotterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schaefer, Catherine" sort="Schaefer, Catherine" uniqKey="Schaefer C" first="Catherine" last="Schaefer">Catherine Schaefer</name>
<affiliation wicri:level="2"><nlm:aff id="A16">Division of Research, Kaiser Permanente, Northern California, Oakland, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Research, Kaiser Permanente, Northern California, Oakland, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schenk, Jeannette M" sort="Schenk, Jeannette M" uniqKey="Schenk J" first="Jeannette M." last="Schenk">Jeannette M. Schenk</name>
<affiliation wicri:level="2"><nlm:aff id="A32">Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A33">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
<affiliation wicri:level="4"><nlm:aff id="A13">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, and Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, and Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A34">Human Genetics Foundation, Torino, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Human Genetics Foundation, Torino</wicri:regionArea>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stampfer, Meir J" sort="Stampfer, Meir J" uniqKey="Stampfer M" first="Meir J." last="Stampfer">Meir J. Stampfer</name>
<affiliation wicri:level="2"><nlm:aff id="A14">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A35">Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stattin, P R" sort="Stattin, P R" uniqKey="Stattin P" first="P R" last="Stattin">P R Stattin</name>
<affiliation wicri:level="1"><nlm:aff id="A36">Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå</wicri:regionArea>
<wicri:noRegion>Umeå</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tamakoshi, Akiko" sort="Tamakoshi, Akiko" uniqKey="Tamakoshi A" first="Akiko" last="Tamakoshi">Akiko Tamakoshi</name>
<affiliation wicri:level="1"><nlm:aff id="A37">Hokkaido University Graduate School of Medicine, Sapporo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Hokkaido University Graduate School of Medicine, Sapporo</wicri:regionArea>
<wicri:noRegion>Sapporo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tangen, Catherine M" sort="Tangen, Catherine M" uniqKey="Tangen C" first="Catherine M." last="Tangen">Catherine M. Tangen</name>
<affiliation wicri:level="4"><nlm:aff id="A38">SWOG Statistical Center, Fred Hutchinson Cancer Research Center, and Department of Biostatistics, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>SWOG Statistical Center, Fred Hutchinson Cancer Research Center, and Department of Biostatistics, University of Washington, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
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<region type="région" nuts="1">Angleterre de l'Est</region>
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<orgName type="university">Université de Cambridge</orgName>
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</author>
<author><name sortKey="Weiss, Noel S" sort="Weiss, Noel S" uniqKey="Weiss N" first="Noel S." last="Weiss">Noel S. Weiss</name>
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<author><name sortKey="Ziegler, Regina G" sort="Ziegler, Regina G" uniqKey="Ziegler R" first="Regina G." last="Ziegler">Regina G. Ziegler</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Key, Timothy J" sort="Key, Timothy J" uniqKey="Key T" first="Timothy J." last="Key">Timothy J. Key</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
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<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
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<orgName type="university">Université d'Oxford</orgName>
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<author><name sortKey="Allen, Naomi E" sort="Allen, Naomi E" uniqKey="Allen N" first="Naomi E." last="Allen">Naomi E. Allen</name>
<affiliation wicri:level="4"><nlm:aff id="A39">Clinical Trials Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Trials Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
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<orgName type="university">Université d'Oxford</orgName>
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<series><title level="j">Cancer research</title>
<idno type="ISSN">0008-5472</idno>
<idno type="eISSN">1538-7445</idno>
<imprint><date when="2016">2016</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Humans</term>
<term>Insulin-Like Growth Factor I (metabolism)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prostatic Neoplasms (blood)</term>
<term>Prostatic Neoplasms (epidemiology)</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Facteur de croissance IGF-I (métabolisme)</term>
<term>Facteurs de risque</term>
<term>Humains</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Tumeurs de la prostate (sang)</term>
<term>Tumeurs de la prostate (épidémiologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Insulin-Like Growth Factor I</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Prostatic Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Prostatic Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur de croissance IGF-I</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Tumeurs de la prostate</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Tumeurs de la prostate</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Facteurs de risque</term>
<term>Humains</term>
<term>Mâle</term>
<term>Sujet âgé</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">The role of insulin-like growth factors (IGFs) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, IGFBP-3) and prostate cancer risk, we pooled individual participant data from 17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 control participants. Conditional logistic regression was used to estimate the odds ratios (ORs) for prostate cancer based on the study-specific fifth of each analyte. Overall, IGF-I, IGF-II, IGFBP-2, and IGFBP-3 concentrations were positively associated with prostate cancer risk (Ptrend all ≤ 0.005), and IGFBP-1 was weakly inversely associated with risk (Ptrend = 0.05). However, heterogeneity between the prospective and cross-sectional studies was evident (Pheterogeneity = 0.03), unless the analyses were restricted to prospective studies (with the exception of IGF-II, Pheterogeneity = 0.02). For prospective studies, the OR for men in the highest versus the lowest fifth of each analyte was 1.29 (95% confidence interval=1.16-1.43) for IGF-I, 0.81 (0.68-0.96) for IGFBP-1, and 1.25 (1.12-1.40) for IGFBP-3. These associations did not differ significantly by time-to-diagnosis or tumor stage or grade. After mutual adjustment for each of the other analytes, only IGF-I remained associated with risk. Our collaborative study represents the largest pooled analysis of the relationship between prostate cancer risk and circulating concentrations of IGF-I, providing strong evidence that IGF-I is highly likely to be involved in prostate cancer development.</p>
</div>
</front>
</TEI>
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<li>Université de Washington</li>
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Serveur d'exploration sur les relations entre la France et l'Australie

A meta-analysis of individual participant data reveals an association between circulating levels of IGF-I and prostate cancer risk

A meta-analysis of individual participant data reveals an association between circulating levels of IGF-I and prostate cancer risk

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